Discontinuation Syndrome

Because it leaves your body so quickly, weaning off Zoloft too quickly can cause discontinuation syndrome. Discontinuation syndrome can occur for anyone, but it is most common in people who have been on Zoloft for many months or years. It can be unsettling because the symptoms might mimic those for which you sought treatment in the first place; in fact, you might even become concerned that your depression or anxiety symptoms are reappearing.

Symptoms When Weaning Off Zoloft

The symptoms of discontinuation syndrome may include:

FatigueUpset stomachMuscle painInsomniaAnxietyAgitationDizzinessHallucinationsBlurred visionIrritabilityTingling sensationsVivid dreamsSweating or electric shock sensations

Some people will experience only minor symptoms and may not make the connection with the changes in their medication regimen. For others, the symptoms are so debilitating that they feel they cannot stop their antidepressant for fear of how it will interfere with their lives.

Tapering to Prevent Discontinuation Syndrome

The best way to avoid or minimize these symptoms is to taper off Zoloft gradually. Consult your physician before attempting to taper. There are not any hard and fast rules for tapering off Zoloft. One person may do it within a short time, while another may take longer. Some may even need to use liquid Zoloft or split their pills in half in order to taper in smaller increments. A liquid formulation of Zoloft, which your doctor must prescribe, allows you to easily measure out smaller quantities of the medication than what is available in pill form. Pills can be split by obtaining an inexpensive device called a pill splitter from your local pharmacy.

Tips for Weaning Off Zoloft Comfortably

The best way to avoid severe discontinuation symptoms is to reduce your dose gradually under your doctor’s supervision. If your symptoms are severe, you might have to wean more slowly. The symptoms will pass in time as your brain adapts to the new dosage. Consult your healthcare provider to develop a weaning regimen that works for you. It will depend on how long you have been taking Zoloft, your current dosage, and how you respond to the tapering.

Work With Your Mental Health Professional

It may be tempting to quit your medication as soon as you start to feel better, but going off of it too soon can cause a relapse. In general, you should stay on your medication for at least four to nine months, and if you’ve struggled with depression three or more times, you should wait at least two years. Talk to your mental health professional about whether or not it’s a good time to discontinue your medication and how to do it.

Follow the Plan

Make sure you taper off according to your doctor’s direction. It may take longer than you think it should, but it’s important to go slowly, so your brain has adequate time to adjust. It is OK to call your doctor and let them know that you wish to discontinue your medication more slowly if you are experiencing uncomfortable withdrawal symptoms.

Get Outside Support

Keep in touch with your mental health professional, especially if you are having withdrawal symptoms. Think about involving a close friend or family member as well, since this person can potentially see issues you may be having that you don’t notice.

Consider Psychotherapy

Therapy, particularly cognitive-behavioral therapy (CBT), can be extremely helpful in keeping depression symptoms at bay by helping you learn how to identify negative thought patterns and change them. Studies have also shown that psychotherapy decreases the likelihood of a relapse.

Stay Healthy

Eat nutritious, balanced meals and snacks, exercise regularly, get enough sleep, and participat in activities you enjoy. Exercise, in particular, can help increase serotonin levels, which in turn boosts mood. Just get that workout done at least several hours before bedtime, or the rush of adrenaline and endorphins you feel may interfere with your sleep.