What Is Serum Blood Level?
Blood serum is the liquid part of the blood that contains no clotting factors or blood cells. When doctors check for serum blood levels, they are usually checking for lithium levels in the bloodstream to be sure that the right dosage is being administered. If other medications are being taken, blood serum levels could be monitored regularly to ensure that lithium is not interfering with the medication. Specifically, the therapeutic range for lithium has been established at 0.6 - 1.2 mmol/L. Within this range, most people will respond to the drug without symptoms of toxicity.
Medications That Require Testing
In addition to lithium, some medications used to treat bipolar disorder require serum blood level testing. Other medications that require serum blood level testing include Tegretol (carbamazepine) and Depakote/Depakene (sodium valproate, valproic acid) as well as certain tricyclic antidepressants such as Pamelor (nortriptyline) and Anafranil (clomipramine). Testing serum blood levels are usually done before medication is prescribed and follow-up can be as soon as one week up to every 6 months or more, depending on your physician’s treatment strategy and how the medication is affecting your bipolar disorder. The test is usually performed by a professional phlebotomist in a lab or clinic setting. The blood is then separated into serum using a centrifuge. This separates the serum to be tested.
Serum Blood Levels and Your Kidneys
Long-term lithium treatment can result in chronic kidney disease. For this reason, serum blood levels may be monitored to check kidney function while the medication is being given for bipolar disorder. For kidney function in lithium treatment, a 24-hour urine collection may also be done to measures total volume output, creatinine levels, and creatinine clearance, and compares it to the norm based on weight and height (total square footage of surface area). Other medications used for bipolar disorder may also cause kidney issues depending on how long and how frequently the drugs are used. A total serum protein test may be conducted to check organ function. Specifically, globulin and albumin levels will be checked.
Other Important Serum Blood Tests
Your doctor may test your serum blood levels for sodium, magnesium, cholesterol and other important levels that may indicate changes in your blood profile. Serum blood levels showing increased levels of these markers may spell an increased risk for chronic medical conditions or psychotic episodes. Talk to your doctor if you feel serum blood level testing may help you assess your health.
